![]() Rape-exposed women ( n = 852) were recruited from rape clinics in the Rape Impact Cohort Evaluation (RICE) umbrella study. ![]() ![]() We aimed to: (1) identify epigenome-wide differences in methylation profiles between rape-exposed women with and without PTSD at 3-months post-rape, in a demographically and ethnically similar group, drawn from a low-income setting (2) validate and replicate the findings of the epigenome-wide analysis in selected genes ( BRSK2 and ADCYAP1) and (3) investigate baseline and longitudinal changes in BRSK2 and ADCYAP1 methylation over six months in relation to change in PTSD symptom scores over 6 months, in the combined discovery/validation and replication samples ( n = 96). DNA methylation changes may confer risk or protection for PTSD following rape by regulating the expression of genes implicated in pathways affected by PTSD. Rape is associated with a high risk for posttraumatic stress disorder (PTSD).
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